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Informative Articles

7 Ways To Conquer Acne
Reports show that over 90 percent of all adolescents and almost 25 percent of all adults suffer from acne at some time. Acne affects males and females worldwide, regardless of nationality. The most effective methods to combat acne include a...
Arthritis Management Through Diet
The term “arthritis” refers to the chronic inflammation of joints throughout the body. Arthritis is one of the most rapidly growing chronic conditions in North America. Osteoarthritis, the most common form of arthritis, is also known as wear and...
Beauty Today: All Smoke and Mirrors?
Did you ever notice that the bar is continually being raised on exactly what physical characteristics define beauty? As I sit in front of the TV, I am bombarded by beauties with pouty lips, perfect bone structure, flawless skin, more "voluptuous"...
Hair loss causes - baldness triggers and treatments
Baldness is a problematic condition for a large majority of the male population. Find out how to effectively identify different hair loss causes and how to remove their negative effects by finding the appropriate treatment. Hair loss causes -...
Your Guide To Acne Skin Care
Contrary to popular belief, acne is not caused by dirty pores or eating chocolate. Acne is actually caused by overactive sebaceous glands. Hormones in you body cause acne to appear. Acne is extremely common in people ages 12-24, when our hormones...
 
Spironolactone in the treatment of acne

In his article on acne published recently in the New England Journal of Medicine James (1) mentions that androgen antagonist spironolacton is often useful in women with hyperandrogenism. However, it would be important to point out, that the effectiveness of this treatment cannot be determined due to the small sample populations involved in the trials, as has been shown in recent metaanalysis. (2) It should be also emphasized that although the long-term use of spironolactone in the treatment of acne in women appears to be safe, its side-effects seem to be high. (3) On the other hand, it is worth mentioning that spironolactone in addition to its antiandrogenic effects might also have antiinflammatory potential. (4) This emphasizes the need for further properly designed trials with relevant outcomes to provide robust estimates of the size and mechanism of any treatment effects. Because of its long half-life spironolactone should be given once daily and not in divided doses as recommended by James. This might


increase the compliance which is important in prolonged therapy to achieve maximal benefits. (5)


1. James WD. Clinical practice. Acne. N Engl J Med 2005;352:1463-72.

2. Farquhar C, Lee O, Toomath R, Jepson R. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. Cochrane Database Syst Rev 2003;(4):CD000194.

3. Shaw JC, White LE. Long-term safety of spironolactone in acne: results of an 8-year followup study. J Cutan Med Surg 2002;6:541-5.

4. Hansen PR, Rieneck K, Bendtzen K. Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells. Immunol Lett 2004;91:87-91.

5. McEvoy B, Nydegger R, Williams G. Factors related to patient compliance in the treatment of acne vulgaris. Int J Dermatol 2003;42:274-80.


About the author:

Dr. Michal R. Pijak is a consultant in rheumatology, allergy and clinical immunology at the University Hospital in Bratislava, Slovakia.



 

Acne.org
Information on acne, medications and treatment of scars. Includes a regimen for keeping skin clear.
www.acne.org
 
AcneNet
Dermatologist-reviewed information about acne, which lets people know that today virtually every case of acne can be resolved.
www.skincarephysicians.com
 
What is Acne?
Information about the different types of acne lesions and what causes acne to develop.
www.skincarephysicians.com
 
Questions and Answers About Acne
Illustrated information on causes of acne skin lesions, and tips and information on common treatments, their side effects, and current research.
www.niams.nih.gov
 
Acne Resource Center
Acne, Nutrition, Research on Acne and Important Tips for Getting Acne Free.
www.acne-resource.org
 
Acne - Wikipedia, the free encyclopedia
Acne is a group of skin rashes that have different causes. Acne vulgaris - most commonly experienced around puberty, typically of the face and ...
en.wikipedia.org
 
Acne vulgaris - Wikipedia, the free encyclopedia
Different types of Acne Vulgaris: A: Cystic acne on the face, B: ... The vernacular term bacne or backne is often used to indicate acne found specifically ...
en.wikipedia.org
 
MedlinePlus: Acne
From the National Institutes of Health; Questions and Answers about Acne (National Institute of ... Select services and providers for Acne in your area. ...
www.nlm.nih.gov
 
MedlinePlus Interactive Tutorials: Acne
Acne. Start Tutorial. Starts multimedia presentation with questions. Requires Flash Player. Download Flash. download button for flash player. ...
www.nlm.nih.gov
 
Acne Treatment by AcneHelper.com
Resource for acne treatments and prevention. Learn tips and techniques to stop pimples, zits and blackheads for good.
www.acnehelper.com
 
Acne
Acne Creative bring brands to life through advertising, design and product ... Commercials, music videos and other film formats are made by Acne Film. ...
www.acne.se
 
Acne Jeans
About · Collection · Acne Studios · Contact · Press/Retailer · Work at Acne Jeans · Newsletter · Shop (EU). Copyright © Acne Jeans.
www.acnejeans.com
 
Acne
If you're almost a teen, chances are pretty good that you have some acne. About 8 in 10 preteens and teens have acne, along with many adults.
www.kidshealth.org
 
Acne - treatment and causes of pimples and blackheads
What are the causes of acne and which skin treatments are most effective - BUPA health information factsheet.
hcd2.bupa.co.uk
 
Natural Acne Treatment Information
Acne and Diet · The Risks and Side Effects of Prescription Acne Medications ... This is a great jumping off point for natural acne treatments. ...
www.absoluteacneinfo.com
 
ASG www.stopspots.org ! | Index Acne, Pimples, Blackheads, Zits ...
Information and support on acne, including top ten tips, beauty tips and problems.
www.stopspots.org
 
Acne.net - Acne & Skin Treatment Resource
Introduction to several forms of acne and some available treatments, by a dermatologist and medical school professor.
www.acne.net
 
Acne.com - Acne Treatment Information
Acne.com - Acne Treatment Information. Your source for Acne information on the web. Learn more about what causes acne and how you can fight acne.
www.acne.com
 
Acne – Complete medical information regarding acne and its ...
Complete medical explanation produced by doctors regarding acne, its causes, myths of causes, treatment on your own, and treatment by doctors.
www.medicinenet.com
 
AAD - Acne
Acne is a skin condition which has plugged pores (blackheads and whiteheads), inflamed pimples (pustules), and deeper lumps (nodules).
www.aad.org
 
 

 
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