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Are Diet Pills the Answer?
There has been a lot of flak with how USA has been flirting with health problems because of obesity. More and more people are getting drowned in the onslaught of fast food and junk foods. Remember the movie "Upsize Me"? It played a parody on...
Are You Losing Fat Or Muscle?
I often have to catch myself when speaking with clients or newsletter subscribers when I use the terms "weight loss" or "losing weight". I mistakingly use these terms on my site and in my newsletters even though I probably shouldn't. ...
Dumbbell Workouts - A Smart Way To Exercise
Dumbbell workouts have been around for many years, especially as part of weight training equipment and programs. Fad workouts and equipment have come and gone, but dumbbell workouts have remained an easy, inexpensive way to get in shape and...
The Power Workout
Not enough hours in the day? Feeling the crunch when it comes to finding time for just your own needs? If exercise is important to you, you might do well to consider the following: Scenario: I really want to get in shape, but I work all day and...
What is Self Mastery? - Part 2
To continue with our overview of the physical component of self mastery, it goes without saying that walking is a valuable aerobic exercise - but you have options. You can use a bicycle for nice days, or use indoor aerobic exercise equipment for use...
 
What is a Botox Injection anyway?

The cosmetic form of botulinum toxin, often referred to by its product name Botox, is a popular non-surgical injection that temporarily reduces or eliminates frown lines, forehead creases, crows feet near the eyes and thick bands in the neck. The toxin blocks the nerve impulses, temporarily paralyzing the muscles that cause wrinkles while giving the skin a smoother, more refreshed appearance. Studies have also suggested that Botox is effective in relieving migraine headaches, excessive sweating and muscle spasms in the neck and eyes. Botulinum neurotoxin is produced by the gram-negative anaerobic bacterium Clostridium botulinum.
Eight serologically distinct botulinum neurotoxins exist, designated as A, B, C1, C2, D, E, F, and G. Seven are associated with paralysis. Types A, B, E and, rarely, F and G are associated with human botulism.
Dose
The dose of botulinum toxin is expressed in mouse units. One unit is equal to the amount that will kill 50% of a group of 18- to 22-g Swiss Webster mice when injected intraperitoneally. The human lethal dose (LD) for BOTOX (botulinum type A purified neurotoxin complex) is estimated at approximately 3000 units. BOTOX injections of less than 100 units usually are used for cosmetic purposes and of less than 300-600 units for other purposes, thereby allowing a wide safety margin. Recognizing that doses are not interchangeable among different formulations of botulinum toxin (BOTOX, Dysport, Myobloc) is important; to achieve similar clinical effects, different doses are used.
Botulinum toxin formulations
BOTOX is a sterile lyophilized form of botulinum toxin type A. It is produced from a culture of the Hall strain of C botulinum and purified by a series of acid precipitations to a crystalline complex containing the toxin and other proteins. The FDA approved BOTOX in December 1989 as an orphan drug for the treatment of strabismus, hemifacial spasms, and blepharospasm. BOTOX is distributed in 100-unit vials.
The original batch of neurotoxin prepared by Shantz in November 1979 (designated batch 79-11) constituted the original BOTOX formulation and was used until December 1997. It was replaced by a new neurotoxin complex batch designated BCB 2024. The new bulk batch is 5-6 times more potent on a weight basis. In a 100-unit vial, only 4.8 ng of neurotoxin is needed compared to 25 ng of 79-11. The new BOTOX is comparable in clinical efficacy and safety to the old, and a unit dose of new BOTOX provides an equivalent response to the same unit dose of old BOTOX. Hopefully, the reduced protein load of the new BOTOX leads to reduced immunogenicity and a lower incidence of neutralizing antibody formation.
Dysport is another


formulation of botulinum toxin type A available in Europe and a few other countries. It is prepared using column-based purification techniques and distributed in 500-unit vials that can be stored at room temperature. BOTOX and Dysport are both botulinum toxin type A preparations but are quite distinct from one another. BOTOX is approximately 4 times more potent on a per unit basis, and Dysport doses often are approximately 4 times the BOTOX doses used to generate a similar clinical effect. Differences in these toxins may relate to differences in the strain of bacterium, preparation, diffusion, and potency testing.
Myobloc is a botulinum toxin type B preparation currently in clinical trials. It is anticipated that it will be distributed as a solution. Little information is available concerning the cosmetic use of Dysport and Myobloc. The remainder of this article therefore focuses on BOTOX, and all unit doses refer to BOTOX unless otherwise specified.
Reconstitution and storage
Store BOTOX in a freezer at or below -5°C. The package insert recommends reconstitution of BOTOX using sterile saline without preservative; 0.9% sodium chloride is the preferred diluent. Some investigators suggest that reconstitution with sterile saline solution with preservative (0.9% benzyl alcohol) reduces microbial contamination and provides a weak local anesthetic effect. However, contamination is rarely a problem, and the anesthetic effect is modest.
BOTOX is denatured easily by bubbling or agitation; gently inject the diluent onto the inside wall of the vial. Discard the vial if a vacuum does not pull the diluent in. The final dilution of BOTOX is mostly a matter of personal preference; 100 units commonly are reconstituted in 1-10 mL of diluent. Theoretically, more concentrated solutions reduce reliability in delivering a specific unit dose, and more dilute solutions lead to greater diffusion of the toxin. The authors prefer to use 2 mL of diluent to prepare a solution of 5 U/0.1 mL (50 U in a 1-mL tuberculin syringe if that much is to be used). Use a 30-gauge 1-inch needle to perform the injections.
Once reconstituted, keep BOTOX refrigerated at 2-8°C. The package insert indicates that reconstituted BOTOX should be used within 4 hours. One study found no loss of activity at 6 hours but a 44% loss after 12 hours and a 70% loss with refreezing at 1-2 weeks. Other authors report no substantial loss of potency in a 10 U/1 mL reconstituted solution kept refrigerated for 1 month. Most practitioners discard unused reconstituted BOTOX after 1-7 days.

About the Author

For more more information about botox injections please visit http://www.botox-injection-information.net

 

Aerobic - Wikipedia, the free encyclopedia
From Wikipedia, the free encyclopedia. Jump to: navigation, search. Look up Aerobic in ... Retrieved from "http://en.wikipedia.org/wiki/Aerobic" ...
en.wikipedia.org
 
Aerobic exercise - Wikipedia, the free encyclopedia
Aerobic exercise includes any type of exercise, typically those performed at ... In general, aerobic exercise is one performed at a moderately high level of ...
en.wikipedia.org
 
Aerobic Exercise
The American College of Sports Medicine (ACSM) defines aerobic exercise ... The important idea behind aerobic exercise today, is to get up and get moving! ...
www.gsu.edu
 
Turnstep.com
Turnstep is a large community of aerobics enthusiasts featuring over 10000 patterns, an active bulletin board, and more.
www.turnstep.com
 
Aerobic Respiration
Aerobic respiration is the release of energy from glucose or another organic substrate in the presence of Oxygen. Strictly speaking aerobic means in air, ...
www.purchon.com
 
AFAA – Aerobics & Fitness Personal Trainer Certification & Group ...
AFAA offers personal trainer certification, group exercise certification and other fitness certifications for fitness professionals.
www.afaa.com
 
Jacki Sorensen's Aerobic Programs SuperSite
Fun aerobics classes for a complete workout. Jacki Sorensen's Aerobic Dancing, Workout and StrongStep classes are throughout the US and other countries.
www.jackis.com
 
The Cooper Institute
Nonprofit research and education organization dedicated to preventive medicine. Information on training, certifications, and products.
www.cooperinst.org
 
BodyTrends Health & Fitness: Search
At BodyTrends Find thousands of health, fitness and exercise products from top manufacturers. Offering related fitness articles and advice.
www.bodytrends.com
 
Carmen Electra's Official Aerobic Striptease Strip Workout
Carmen Electra's Aerobic Striptease Workout Video.
www.aerobicstriptease.com
 
Aerobic Exercise
A program of regular aerobic exercise can help you avoid chronic diseases ... To strengthen your heart, you should do aerobic exercise intensely enough to ...
orthoinfo.aaos.org
 
Bush Aerobics - Miniclip Games - Play Free Games
Help President Bush get fit and ready for his day.
www.miniclip.com
 
Aqua-Aerobic Systems
Aqua-Aerobic Systems, Inc. provides wastewater treatment systems for Aeration, Mixing, Filtration, Controls, SCADA, Biological Processes, Membranes.
www.aqua-aerobic.com
 
MedlinePlus Medical Encyclopedia: Aerobic
Aerobic. Printer-friendly version · Email this page to a friend. Contents of this page: ... Aerobic organisms · Aerobic organisms. Definition Return to top ...
www.nlm.nih.gov
 
Aerobic, Exercise and Fitness Videos by Cathe Friedrich
Geared towards the advanced home exerciser with information about Cathe Friedrich's aerobic and fitness videos.
www.cathe.com
 
Aerobics, Aerobic Spot, Step, Kickboxing, Choreography, Strength ...
Fitness center offering exercise classes, step aerobics, kickboxing, fitness tips, and strength training.
www.aerobicspot.com
 
ExRx Aerobic Conditioning
ExRx.net is a resource for the exercise professional, coach, or fitness enthusiast.
www.exrx.net
 
Aerobics Music - Step Aerobic Music - Exercise Music - Fitness Music
Aerobics music for aerobic exercise workouts and fitness classes - the largest selection in the world!
www.aerobicsmusic.com
 
Jumpybumpy....aerobics music and fitness videos
Instructor portal offering aerobics and step choreography, videos and music, conventions and workshops, trainer listing.
www.jumpybumpy.com
 
Step aerobics choreography, videos, music, terms at Stepcenter.com
Step aerobics choreography (hundreds of animated moves and patterns), videos, step language dictionary, aerobic music board, training tips, aerobic links ...
www.stepcenter.com
 
 

 
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