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How to Diagnose Mesothelioma
Mesothelioma diagnosis is very important as far as an early
treatment is considered. It helps with better pain management.
Mesothelioma diagnosis is confusing as the symptoms mimic many
lung infections
Don't sit there and keep guessing....
Mesothelioma Fact - Alarming Truth
Lately many people have been looking for mesothelioma fact and information. The startling mesothelioma fact is that Mesothelioma Cancer is a rare cancer but every year about 2,000 new cases of mesothelioma are diagnosed in the United States and this...
Mesothelioma: More About this Asbestos Cancer
Cancers and other forms of diseases are usually named according to the part of the body or the internal organ where abnormal growth of malignant cells takes place. In the case of Mesothelioma, the abnormal cells grow in the mesothelium, a...
The dangers of asbestos
If you read the newspaper or watch the nightly news, chances are you've heard about some of the dangers of asbestos. What is often ignored in these messages, however, is that asbestos also has a number of useful properties. If used responsibly and...
What Are The Four Stages of Mesothelioma Cancer?
One rare form of cancer is called Mesothelioma, a malignant tumor in the mesothelial tissues of the lungs and the abdomen, arising from the inhalation of asbestos. Its rarity is one of the reasons why a lot of people are not aware of this kind of...
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Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestos
Sarcomatoid Mesothelioma is a quite uncommon type of cancer caused due to asbestos exposure. While it is difficult to diagnose Sarcomatoid Mesothelioma, it hardly responds to any type of therapy. This is the most serious of all asbestos-related diseases. The possibility of finding this type of cancer is on the lips and the larynx. However, in certain cases it may affect the oral cavity as well. Like all other forms of mesothelioma cancers, this cancer is a fatal disease and hardly responds to any method of treatment. Even though radiation therapy is recommended for the treatment of these cancerous tumors, but some of them may not be radiosensitive and may defy radiation for treatment.
Diagnosis of Sarcomatoid Mesothelioma:
The differentiation of sarcomatoid mesothelioma from other cell tumors by light microscopy is quite difficult. The role of immunohistochemistry is also not well defined in its diagnosis. Since sarcomatoid mesothelioma is not always cytokeratin-negative, the distinction between it and sarcoma is not always possible. In this context, the doctors undertook a study to investigate the utility of diagnostic immunohistochemistry for distinguishing sarcomatoid mesothelioma from its histological mimics, high-grade sarcoma and pulmonary sarcomatoid carcinoma.
For its study, the researchers stained the mesotheliomas with sarcomatoid components. They assessed the intensity and
distribution of staining with the help of a semi quantitative scale. Only tumors with unequivocal staining were considered positive for tabulation. Then they compared the immunophenotypic profiles of these tumors with 24 high-grade sarcomas. The sarcomatoid carcinomas were also stained for thyroid transcription factor-1 (TTF-1).
The study showed that Cytokeratin 5/6 stained most of the epithelioids but the sarcomatoids were rarely stained. On the other hand, Calretinin and thrombomodulin each stained 70% of sarcomatoid. All 10 sarcomatoids were negative for TTF-1. This led to the conclusion that a wide immunophenotypic overlap exists among different sarcomatoids. Cytokeratin and calretinin have the most value in differentiating different sarcomatoids. Clinicopathological data, especially information about the gross appearance of the tumor is quite important for sarcomatoid tumors. Thus, it should be noted and carefully correlated with microscopic and immunohistochemical findings.
About the Author: Kirsten Hawkins is a asbestos and mesothelioma specialist from Nashville, TN. Visit http://www.asbestosblog.org/ for information on asbestos reform, mesothelioma lawsuit news, and more.
Source: www.isnare.com
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