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Frequently Asked Questions about Mesothelioma
Many people have never heard of Mesothelioma and are unaware of its symptoms. Although considered a rare form of cancer, each year the number of cases grows. With the prevalence of this disease on the rise, it is critical to understand why and how...
Is There Asbestos In Your Floor?
A couple of years ago, I went to replace a vinyl floor in a basement level bathroom of my house. As I lifted up the old flooring I found the mastic was white with a fibrous look to it. Because my house was built over 20 years ago, I was concerned...
The Facts about Pericardial Mesothelioma
Pericardial mesothelioma is a very rare form of mesothelioma and accounts for approximately 5% of all mesothelioma cases. This form of mesothelioma affects the lining that surrounds the heart and is a deadly cancer if not treated agressively in its...
The Signs And Symptoms Of Asbestosis - What To Look Out For
Asbestosis is a disease caused by exposure to high levels to asbestos, a dangerous mineral that can also result in mesothelioma, which is a deadly cancer. It is important for anyone that works or has worked with asbestos – and those that think they...
What You Need to Know about a Mesothelioma Law Suit, Mesothelioma Law and a Mesothelioma Law Firm
There is some important information you should be aware of if you are considering pursuing a Mesothelioma Law Suit. Prior to pursuing a Mesothelioma Law Suit you should seek advice from a reputable Mesothelioma Law Firm and gain an understanding of...
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Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestos
Sarcomatoid Mesothelioma is a quite uncommon type of cancer caused due to asbestos exposure. While it is difficult to diagnose Sarcomatoid Mesothelioma, it hardly responds to any type of therapy. This is the most serious of all asbestos-related diseases. The possibility of finding this type of cancer is on the lips and the larynx. However, in certain cases it may affect the oral cavity as well. Like all other forms of mesothelioma cancers, this cancer is a fatal disease and hardly responds to any method of treatment. Even though radiation therapy is recommended for the treatment of these cancerous tumors, but some of them may not be radiosensitive and may defy radiation for treatment.
Diagnosis of Sarcomatoid Mesothelioma:
The differentiation of sarcomatoid mesothelioma from other cell tumors by light microscopy is quite difficult. The role of immunohistochemistry is also not well defined in its diagnosis. Since sarcomatoid mesothelioma is not always cytokeratin-negative, the distinction between it and sarcoma is not always possible. In this context, the doctors undertook a study to investigate the utility of diagnostic immunohistochemistry for distinguishing sarcomatoid mesothelioma from its histological mimics, high-grade sarcoma and pulmonary sarcomatoid carcinoma.
For its study, the researchers stained the mesotheliomas with sarcomatoid components. They assessed the intensity and
distribution of staining with the help of a semi quantitative scale. Only tumors with unequivocal staining were considered positive for tabulation. Then they compared the immunophenotypic profiles of these tumors with 24 high-grade sarcomas. The sarcomatoid carcinomas were also stained for thyroid transcription factor-1 (TTF-1).
The study showed that Cytokeratin 5/6 stained most of the epithelioids but the sarcomatoids were rarely stained. On the other hand, Calretinin and thrombomodulin each stained 70% of sarcomatoid. All 10 sarcomatoids were negative for TTF-1. This led to the conclusion that a wide immunophenotypic overlap exists among different sarcomatoids. Cytokeratin and calretinin have the most value in differentiating different sarcomatoids. Clinicopathological data, especially information about the gross appearance of the tumor is quite important for sarcomatoid tumors. Thus, it should be noted and carefully correlated with microscopic and immunohistochemical findings.
About the Author: Kirsten Hawkins is a asbestos and mesothelioma specialist from Nashville, TN. Visit http://www.asbestosblog.org/ for information on asbestos reform, mesothelioma lawsuit news, and more.
Source: www.isnare.com
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