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Food Sources That Boost Glutathione Naturally
Glutathione, the body's master antioxidant and detoxifier, is one of the 14 "Superfoods" listed in SuperFoods Rx : Fourteen Foods That Will Change Your Life, co-authored by Dr Steven Pratt. Glutathione levels cannot be increased to a...
Getting the Most from Calcium Supplements
Although a well-balanced diet is the best way to consume vitamins and minerals, some people prefer to take out an "insurance policy" or two in the form of supplements. One thing is for sure; there is no shortage of calcium supplements on the market!...
Increase Semen Production Safely and Effectively
The desire to increase semen production is common among men throughout world and the reasons are various; ranging from hopes of increased fertility to a desire for a more intense orgasmic experience. While many men are content to sit on the...
Pulling The Roots Of Disease
"Anybody who tells you that disease has only one cause, and that drugs and surgery are the solution, is DEAD WRONG." Dr. Ward Coleman, N.D. Unhealthy aging and diseases of the body systems (such as cancer, heart disease, diabetes, immune...
Vitamin Tips: To Fuel Physical Activity
(NC)—Physical activity and athletic performance can be enhanced through good nutrition. This can be achieved by eating the right foods and drinking the right fluids at the right time, coupled with nutritional supplementation. Regular physical...
 
Dietary Supplements and Prescription Drugs - What You Should Know

So much news is made of the occurrence and prevalence of diseases such as cancer and AIDS; and of viruses such as Bird Flu and SARS that one could be easily be mistaken in thinking that humans are a species at risk. Although some of these possible pandemics are a sobering thought, you may take solace in the fact that we have a smaller chance of getting, and a better chance of beating, a damning diagnosis than ever before. In part, this has been achieved through the dual advance of the pharmaceutical and nutritional sciences: we have an arsenal of both nutraceuticals and drugs for prevention, treatment and cure.

At the last big count, 7.5% of Americans aged 18 to 44 take 3 or more prescribed drugs, this rises to a huge 47.6% in those aged 65 or over. At the same time over a third of the US population uses dietary supplements daily and over 20% have used some form of natural product in the past 12 months. When these statistics are put together it would be safe to assume that many people are on at least one drug and nutraceuticals at the same time. What is even more worrying is that an estimated 70% of patients fail to tell their doctor they are undergoing alternative treatment for their problems. Problems like depression, asthma, diabetes, arthritis, allergies, flu and high blood pressure are now so well characterized and supported by drugs that physicians may feel less inclined to investigate the condition, or the person, further.

Side effects of drugs are well known with huge legal cases such as Vioxx bringing the industry and the regulation process into the spotlight. Drug-drug interactions are also well documented and millions of dollars are spent on research and testing to find out exactly what can, and can't, be used concomitantly. However, when it comes to nutraceuticals, few people have much, if any, knowledge about what happens in the body when you take these with prescription medicine. And with scant formal training for herbal products or nutraceuticals in medical school, your doctor may be more in the dark than you are.

Drug Supplements Interactions - Two Rights Can Make a Wrong

Many drugs are cleared from the body by certain enzymes in the liver, especially those from a certain family called cytochrome P450s. These enzymes may also be responsible for breaking down other substances, such as alcohol, nutrients and herbal products. These particular enzymes can be held up by breaking down a nutraceutical you have ingested, while the drug will be circulating in your bloodstream a lot longer than the physician had planned. If you are taking multiple doses of the drug then it can build up to dangerous levels, and if the drug has a narrow window between good effects and harm then overdose is a distinct possibility.

A good example is Digoxin, a cardiovascular drug. If Digoxin is taken with licorice, the levels of the drug in the bloodstream can be increased four fold, the effects and side effects will be increased dramatically


to a possibly lethal endpoint.

Drugs and Nutraceuticals can also have a synergic effect when taken together. They may produce the same reaction in your body or interact in some way to produce unexpected and undesirable results. This can happen with the anti-anxiety drug, Alprazolam or Xanax. When Xanax is taken with the popular herb Kava, also used for anxiety, they can have a drastic effect upon the central nervous system. The reasons are not fully understood but at least one person has been hospitalized with severe mental problems by taking this combination.

Nutraceuticals may also have the opposite effect on these P450 enzymes and they can have what is called an "inductive effect" whereby the nutraceutical boosts the activity of the enzyme to higher than normal levels. The enzyme then breaks down and clears the drug from the body much faster than was expected by your physician. Because the dose of a drug is a very exact calculation, a prescribed amount is designed to stay in the body for a time long enough to be effective. If the drug is cleared early it may have a reduced effect or no effect at all.

Further Information on Drug Dietary Supplement Interactions

You should first and foremost tell your doctor and pharmacist what you are taking. Unfortunately, there is not a high level of understanding in the medical or pharmaceutical world into herbs and nutraceuticals although some research has been conducted into the popular herbs such as St. John's Wort, Ginseng, Gingko, Cayenne, Saw Palmetto and Valerian. A dietician may have better knowledge than your doctor but there are also a number of sources of information concerning prescription drug-dietary supplement interactions on the internet below.

In addition to these resources, one online dietary supplements company, Mitamins, offers a free drug interaction checker before you buy. The website allows the design of a custom multivitamin according to the prescription drugs you are taking. There is also a good library where you can review the latest scientific knowledge on your drug or nutraceutical.

The Merck Manual is a comprehensive resource of up to date medical information and has some good primers on interactions as well as in depth analysis. http://www.merck.com/mmhe/sec02/ch019/ch019a.html

The National Institute of Health's Office of Dietary Supplements has a number of good fact sheets on different supplements http://ods.od.nih.gov/Health_Information/Information_About_Indivi dual_Dietary_Supplements.aspx

Mitamins is an online retailer of custom multivitamins and has over 1,000 formulas to support everything from Alzheimer's, ADD and Ageing to Weight Loss and Cancer. These formulas can be safety checked and adjusted for interaction with over 1,600 drugs. http://www.mitamins.com/



About the author:

Mark is a qualified chemist and writer. He has worked in both the drug development and the dietary supplement industries.

 

Office of Dietary Supplements - HOME
The mission of ODS is to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, stimulating and supporting ...
dietary-supplements.info.nih.gov
 
International Bibliographic Information on Dietary Supplements ...
A database of published, international, scientific literature on dietary supplements including vitamins, minerals, and botanicals.
dietary-supplements.info.nih.gov
 
US FDA/CFSAN - Dietary Supplements: Overview
Overview of dietary supplements and the FDA's role in regulating this group of foods.
www.cfsan.fda.gov
 
All About Nutritional Supplements: Consumers Review Supplements ...
NutritionalSupplements.com is the Internet's premier source for unbiased information about nutritional supplements and prescription drugs.
www.nutritionalsupplements.com
 
Times Online - Supplements
Supplements. ... For information on supplement opportunities in The Times, The Sunday Times and on Times Online, e-mail us at supplements@timesonline.co.uk ...
www.timesonline.co.uk
 
Drug Information and Supplement Information - MayoClinic.com
Research prescription and over-the-counter medications and supplements.
www.mayoclinic.com
 
Supplements : Nature
Journal home > Supplements. Supplements. Latest Insights; Latest Outlooks; Latest Collections ... Order your supplement reprints; Downloadable forms: ...
www.nature.com
 
Bodybuilding.com - Huge Supplements Article Database!
Learn the secrets to using supplements for fast results!
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New Zealand Herald - Supplements
The New Zealand Herald publishes over 60 supplements, features and composites a year - packed ... Links to current supplements carried online are below. ...
www.nzherald.co.nz
 
Dietary supplement - Wikipedia, the free encyclopedia
A prescribed dietary supplement is intended to supply nutrients ... The medical utility and regulatory status of dietary supplements is controversial. ...
en.wikipedia.org
 
Vitamin Supplements - Ask the Dietitian
Got questions about Vitamins or Antioxidant supplements? Ask Joanne Larsen, Registered Dietitian and nutrition counselor.
www.dietitian.com
 
Supplements Canada.com - Canada's Sport Supplement Superstore. Get ...
Sells sports nutrition supplements.
www.supplementscanada.com
 
Food and Nutrition Information Center: Dietary Supplements
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healthymeals.nal.usda.gov
 
Bodybuilding Supplements - Xenadrine, Stacker 2, Hydroxycut ...
Offers articles on supplements, reviews, fitness, routines, workout tips and diet.
www.bodybuildingforyou.com
 
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All major brands of bodybuilding supplements. Weight lifting gloves, belts, and straps. Free newsletter.
www.affordablesupplements.com
 
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Bodybuilding Supplements Exercise Equipment Gakic Life Fitness Treadmills Muscle Milk Elliptical.
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Supplements - legal ways to improve performance and or hasten recovery
Supplements to improve performance. ... Supplements. There are a number of supplements that have been identified as potentially beneficial to the athlete: ...
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Natural Health Herbal, Vitamin and Nutritional Supplements ...
NutraSanus natural health care products, herbal, vitamin and nutritional supplements for a longer healthier life.
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MMWR: Supplements Past Volumes
Volume 55 (2006) MMWR Supplement Issues · Volume 54 (2005) MMWR Supplement Issues · Volume 53 (2004) MMWR Supplement Issues · Volume 52 (2003) MMWR ...
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Bodybuilding Supplements EAS Optimum Nutrition Sports Nutrition ...
KeySupplements.com wholesale bodybuilding supplements sports nutrition health store same day shipping fixed rate.
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