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7 Tips To Kick Your Sugar Habit
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Dietary Fiber May Not Protect Against Colon Cancer
High intake of dietary fiber was not linked to a lower occurrence of colorectal cancer in a recent analysis published in JAMA, which combines data from 13 studies.
Although dietary fiber has been hypothesized to reduce the risk of colorectal cancer, the results of numerous previous studies have been inconsistent.
Ecological correlation studies and many case-control studies have found an inverse association between dietary fiber intake and risk of colorectal cancer.
However, most prospective cohort studies have found no association between dietary fiber intake and risk of colorectal cancer or its precursors (adenomas). Also, randomized clinical trials of dietary fiber supplementation have failed to show reductions in the recurrence of colorectal adenomas.
Nonsignificant Weak Link
Yikyung Park, ScD, formerly of the Harvard School of Public Health, Boston, and colleagues reanalyzed the primary data from 13 prospective cohort studies, including 725,628 men and women who were followed-up for six to 20 years across studies, to see if there was a connection between fiber intake and colorectal cancer risk.
During the follow-up, 8,081 colorectal cancer cases were identified. Among the studies, the median energy-adjusted dietary fiber intake ranged from 14 to 28 grams per day (g/d) in men and from 13 to 24 g/d in women.
The major source of dietary fiber varied across studies with cereals as a major contributor to dietary fiber intake in the European studies, and fruits and vegetables as the main sources in the North American studies.
In the age-adjusted model, dietary fiber intake was significantly associated with a 16 percent lower risk of colorectal cancer in the highest quintile compared with the lowest. This association was attenuated slightly but still remained statistically significant after adjusting for nondietary risk factors, multivitamin use, and total energy intake.
Additional adjustment for dietary folate intake further weakened the association, however. In the final model, which further adjusted for other dietary
factors -- such as red meat, total milk and alcohol intake -- only a nonsignificant weak inverse association was found. Fiber intake from cereals, fruits and vegetables was not associated with risk of colorectal cancer.
Lower Risk of Other Chronic Conditions
"The association between dietary fiber intake and risk of colorectal cancer has been inconsistent among observational studies, and several factors may explain the disparity: potential biases in each study, the failure to adjust for covariates in the multivariate models, and the range of dietary fiber intake," note the authors.
Although they did not find support for the hypothesis that high dietary fiber intake has a major effect on the risk of colorectal cancer, the authors conclude that "a diet high in dietary fiber from whole plant foods can be advised, because this has been related to lower risks of other chronic conditions, such as heart disease and diabetes."
John A. Baron, MD, of Dartmouth Medical School examines the results of the pooled analysis in an accompanying editorial.
"The findings by Park et al… provide at least some indications that dietary fiber of some sort is related in some way to colon or rectal cancer risk," he says.
"Over the short term, wheat fiber or psyllium (soluble fiber) interventions do not seem to affect colorectal carcinogenesis," Dr. Baron acknowledges, "but understanding longer-term relationships with any type of fiber will require more work. Studies like that of Park et al provide valuable help, but unfortunately there is more to do."
About the Author: Tom Harrison is a health journalist for Daily News Central, an online publication that delivers breaking news and reliable health information to consumers, healthcare providers and industry professionals: http://www.dailynewscentral.com
Source: www.isnare.com
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American Diabetes Association Home Page |
Their mission is to prevent and cure diabetes and to improve the lives of all people affected by this disease. Available in English and Spanish. |
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Diabetes Information - American Diabetes Association |
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Diabetes UK home page - Diabetes UK |
Diabetes UK is the largest organisation in the UK working for people with diabetes, funding research, campaigning and helping people live with the ... |
www.diabetes.org.uk |
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Canadian Diabetes Association |
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Diabetes information including treating type 2 diabetes at ... |
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Diabetes |
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CDC Diabetes Public Health Resource |
The diabetes information homepage of the US Centers for Disease Control and Prevention, provided by the CDC’s Division of Diabetes Translation. |
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CDC - Health Topic: Diabetes |
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National Diabetes Information Clearinghouse |
Provides educational materials to increase knowledge and understanding about diabetes among patients, health care professionals, and the general public. |
diabetes.niddk.nih.gov |
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Diabetes mellitus - Wikipedia, the free encyclopedia |
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en.wikipedia.org |
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MedlinePlus: Diabetes |
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MedlinePlus Medical Encyclopedia: Diabetes |
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www.nlm.nih.gov |
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Diabetes |
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diabetes.about.com |
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WebMD Diabetes Health Center - Information on Type 1 and Type 2 ... |
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WebMD Health - 404 Error |
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www.webmd.com |
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Diabetes Overview |
Defines diabetes, including the various types and treatments. Provides information on the impact and cost of the disease, its increasing prevalence, ... |
www.niddk.nih.gov |
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Diabetes News - The New York Times |
A free collection of articles about diabetes published in The New York Times. |
topics.nytimes.com |
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children with DIABETES Online Community |
An online community for kids, families, and adults with diabetes, featuring message boards, chat rooms, and questions/answers from medical professionals. |
www.childrenwithdiabetes.com |
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International Diabetes Institute - Diabetes Research, Education ... |
The International Diabetes Institute is the leading national and international centre for diabetes research, diabetes education and diabetes care. |
www.diabetes.com.au |
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Diabetes New Zealand |
Educates and informs people about diabetes, its treatment, prevention, and cure of diabetes. |
www.diabetes.org.nz |
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