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Bleeding Gums
Bleeding Gums? Bleeding gums can be one sign of periodontal disease, gingivitis, or other serious problems. Other symptoms of poor dental health may include persistent bad breath, toothache, and receding gums. Untreated, bleeding gums and gum...
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How does inhaled insulin work

There has been lots of research in the field of insulin administration. To keep blood sugar under control insulin is injected. P atients would prefer inhaled insulin to injected insulin especially, when sometimes you have to take up to 6 injections daily. The different targets tried for insulin delivery are through the upper airways i.e. the mouth, the nose , the skin and even as suppositories. Oral delivery is not possible due to the acidity of the stomach and the digestive enzymes of the intestines which prevent the insulin molecules to absorb into the blood. Inhaled insulin can reduce or eliminate the daily insulin injections.



There are several systems in developmental phase by different pharmaceutical firms with products like Aerodose R , AERxTM Diabetes Management System, Qdose R and Exubera R .



An advisory panel to the U.S. Food and Drug Administration on September 8 th 2005 recommended approval of Exubera an inhaled insulin for adults with type 1 or type 2 diabetes. It is predicted that Pfizer would launch Exubera in late 2006.Exubera is produced by Sanofi-Aventis and Nektar Therapeutics, a California biotechnology firm (formerly Inhale Therapeutic Systems, Inc.) in partnership with Pfizer.

Other inhalable insulins still on human testing are by Indianapolis-based Lilly and Alkermes Inc., and another is by the Danish firm Novo Nordisk and Aradigm. The Lilly-Alkermes inhaler is small enough to fit in the palm of the hand and is breath-activated, but Exubera, a larger device and it relies on compressed air to operate. The Lilly-Alkermes inhaler is expected to reach the market only by 2008.

How does inhaled insulin work?

The delivery of the Exubera is designed in such a way that this should be small enough to get into the lungs and not large enough to be breathed out. Exubera is a rapid-acting, fine dry-powder insulin. The blister packs are loaded into the inhaler device and a trigger is squeezed to disperse the insulin powder into the


compartment above. When this is inhaled through the mouth the finely powdered air reaches directly into the lungs. Insulin passes through the alveolar wall found in the lung and enters into the blood circulation. Breathing once or twice would be sufficient. The content in the blister pack is 20 % insulin and 80% is not revealed. The insulin is reported to be stable for 6 to 24 months at room temperature. Proper training will also be given to people on how to use the inhaler properly. I nhaled insulin enters the bloodstream more rapidly than by subcutaneous injection.

Blood sugar control was equivalent when compared to injected regular and inhaled regular insulin. There are some concerns about the long term effects of chronic inhalation of a growth protein into the lungs. Some experts are also worried about people exposed to second hand smoke or lung disease like asthma or emphysema especially since there have been minor reductions in breathing efficiency in some patients and some patients reported coughing.

This inhaler is also effective during cold and upper respiratory infections but may not be that effective during pneumonia. Smokers will be excluded from taking the drug because the cells in the lungs will be already damaged due to smoking t heir blood sugar could fall dangerously low with Exubera because they absorb much more inhaled insulin in their lungs than nonsmokers.

Delaying insulin treatment can contribute to higher blood sugar levels, which can lead to complications such as nerve damage, cardiovascular problems, vision loss and kidney disease.

About the author:

Anita cherry is a health enthusiast who offers informative tips on certified organic products. For more information on health visit http://www.healthinfoforyou.com/an/How-does-inhaled-insulin-work. htm

You can reprint this article on your website as long as you do not modify any of the content, and include our resource box as listed above with all links intact and hyperlinked properly.

 

American Diabetes Association Home Page
Their mission is to prevent and cure diabetes and to improve the lives of all people affected by this disease. Available in English and Spanish.
www.diabetes.org
 
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The American Diabetes Association recommends the FPG because it is easier, ... Take the first steps toward better diabetes care by visiting the Diabetes ...
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Diabetes UK home page - Diabetes UK
Diabetes UK is the largest organisation in the UK working for people with diabetes, funding research, campaigning and helping people live with the ...
www.diabetes.org.uk
 
Canadian Diabetes Association
To promote the health of Canadians through diabetes research, education, service, and advocacy.
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Diabetes information including treating type 2 diabetes at ...
Offers dietary recommendations, including recipes and tips on managing blood sugar levels. From GlaxoSmithKline.
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Diabetes
Web site for Diabetes. ... publishes Diabetes. Stanford University Libraries' HighWire Press ® assists in the publication of Diabetes Online ...
diabetes.diabetesjournals.org
 
CDC Diabetes Public Health Resource
The diabetes information homepage of the US Centers for Disease Control and Prevention, provided by the CDC’s Division of Diabetes Translation.
www.cdc.gov
 
CDC - Health Topic: Diabetes
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Provides educational materials to increase knowledge and understanding about diabetes among patients, health care professionals, and the general public.
diabetes.niddk.nih.gov
 
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For diabetes mellitus in pets, see diabetes in cats and dogs. ... Type 1 diabetes mellitus - formerly known as insulin-dependent diabetes (IDDM), ...
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(National Institute of Diabetes and Digestive and Kidney Diseases) - Links to PDF ... Select services and providers for Diabetes in your area. ...
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WebMD Diabetes Health Center - Information on Type 1 and Type 2 ...
Find in-depth information here about diabetes prevention, diet, ... Study Shows Burned-Out Staffers More Likely to Get Type 2 DiabetesGo To Article ...
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WebMD Health - 404 Error
Allergies|Anxiety Disorders|Arthritis|Asthma|Back Pain|Bipolar Disorder|Cancer|Children's Health|Cholesterol|Depression| Diabetes|Diet & Nutrition|Erectile ...
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Diabetes Overview
Defines diabetes, including the various types and treatments. Provides information on the impact and cost of the disease, its increasing prevalence, ...
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Diabetes News - The New York Times
A free collection of articles about diabetes published in The New York Times.
topics.nytimes.com
 
children with DIABETES Online Community
An online community for kids, families, and adults with diabetes, featuring message boards, chat rooms, and questions/answers from medical professionals.
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International Diabetes Institute - Diabetes Research, Education ...
The International Diabetes Institute is the leading national and international centre for diabetes research, diabetes education and diabetes care.
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Diabetes New Zealand
Educates and informs people about diabetes, its treatment, prevention, and cure of diabetes.
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