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7 Tips While Waiting for a Cure for Eczema
If you are the parent of a child with eczema, you know how
uncomfortable this condition can make your child. You have
undoubtedly wondered during treatment if there is a cure for
eczema. Unfortunatly, there isn't. However, there are...
Balancing Your Hormones Naturally -- What To Do First
One of the questions that I frequently get asked is "What steps do I need to take to begin getting my hormones in balance?" The following is what I suggest: 1) Test your hormone levels. This should be done by utilizing both saliva testing and blood...
How to use cascara sagrada as a constipation remedy
Cascara Sagrada comes from the bark of the buckthorn tree. It stimulates your colon to produce stronger contraction than normal. When it does this, it can work on the most difficult and chronic cases of constipation.
It is one of the herbal...
Lifestyle Advice for Angry Type-A Action People
The Wood Personality Type (Inspiration and Strategic Planning for Success without Coffee and Espresso) Chinese Medicine has a system of five body-mind-emotion types. This article explains one of those types. Strategic planning for success is a...
When a Sinus Headache Is Really a Migraine
The concept of sinus headaches runs so deep in the public mind that many people with pain in the fronts of their heads (and even some people with pain in the backs of their heads) automatically assume that it is caused by their sinuses. Moreover,...
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Accutane Side Effects: Should Depression Be A Concern?
Medical professionals and acne-pestered adolescents have no doubts about the effectiveness of the severe acne drug isotretinoin. It’s the looming possibility of side effects such as depression and fetal damage that makes people uneasy when considering using this medication.
Accutane (isotretinoin) is one of Hoffman-LaRoche’s most popular and controversial pharmaceuticals. This week, a study published in the Archives of Dermatology vindicated isotretinoin from causing depression. In this report, Christina Y. Chia, MD, from Saint Louis University Health Sciences Center, St. Louis, and colleagues examined whether patients with moderate to severe acne treated with isotretinoin experienced an increase in depressive symptoms compared with patients treated with a topical antibiotic, topical retinoid, and an oral antibiotic.
Dr. Chia found that “The use of isotretinoin in the treatment of moderate-severe acne in adolescents did not increase depressive symptoms. On the contrary, our study shows that treatment of acne improves depressive symptoms”.
Five years earlier, in 2000, the isotretinoin-depression link still appeared misleading. That time, the Archives of Dermatology posted study, headed by Dr. Susan S. Jick, from the Boston University School of Medicine, which found no evidence that isotretinoin increases the risk for depression, suicide, or other psychiatric disorders.
Even though isotretinoin finds ample support among dermatologists and psychiatrists, a host of parents, politicians and medical professionals hail isotretinoin as a medical misfortune.
For instance, Dr. David J. Graham, the Associate Director for Science and Medicine in FDA’s Office of Drug Safety, recently warned that Accutane should be taken off the market. And while there are few studies with any negative observations about isotretinoin, Dr. Douglas Bremner’s research at of the Emory University School of Medicine has linked isotretinoin treatment with changes in brain function. At the conclusion of this study, published in the American Journal of Psychiatry, Dr. Bremner concurred with Dr. Graham’s view that isotretinoin proves too dangerous for human use.
Dr. Bremner explains that to invoke depression, isotretinoin must influence the brain. During the
investigation, brain function of the subjects was measured using positron emission tomography (PET) before and after four months of treatment with isotretinoin. Isotretinoin treatment was associated with decreased brain metabolism in the orbitofrontal cortex- the area of the brain known to mediate symptoms of depression. Yet, there were no differences in severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment.
The pessimistic effects of isotretinoin also caught the attention of Diane K. Wysowski PhD. Dr. Wysowski noted that in June 2000, isotretinoin ranked among the top 10 drugs linked to depression and suicide attempts in the FDA's Adverse Event Reporting System database. In 2001, Dr. Wysowski examined isotretinoin’s depression inducing potential and posted her findings in the Journal of the American Academy of Dermatology. Dr. Wysowski concluded that more studies of isotretinoin are needed.
She also advised patients and their parents to immediately report mood swings and symptoms that are suggestive of depression such as sadness, crying, loss of appetite, unusual fatigue, withdrawal, and inability to concentrate to their prescribing physician. These protective measures can avoid more serious side effects and permit appropriate treatment, including consideration of drug discontinuation and referral for psychiatric care.
While dissension among researchers still exists about whether or not isotretinoin causes depression, one idea most of them can agree on is that more research on the side effects of isotretinoin are desirable. If you are not in the mood for being an isotretinoin guinea pig, Geoffrey Redmond MD, author of The Good News about Women’s Hormones, suggests using hormone therapy and/or using Retin-A if isotretinoin seems too chancy for you.
About the Author
Health author and Stanford University graduate Naweko San-Joyz lovingly writes from her home in San Diego. Her works include “Acne Messages: Crack the code of your zits and say goodbye to acne” (ISBN: 0974912204) and the upcoming work “Skinny Fat Chicks, Why we’re still not getting this dieting thing” (ISBN: 0974912212) for release in June of 2005. For useful acne self-help articles visit http://www.Noixia.com
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