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A Natural Hormone Supplement - What Is It And Why Use It?
A natural hormone supplement is a hormone that is identical to what occurs naturally in the body. Most prescription drugs are not the same as a natural hormone supplement. Why?
In the USA since the late 1800's, U.S....
How Effective are Oral Hyaluronic Acid Supplements?
There is a paradox of sorts when dealing with injections versus oral supplements. Many people would much rather take an oral supplement than have an injection administered. However, the efficacy of injections has been proven to a greater extent than...
Stevia, The Perfect Sweetener, Whoops supplement
We are all aware that sugar is not our friend. Sugar increases
insulin levels and may lead to a myriad of diseases such as high
blood pressure, heart disease, obesity, inflammation, premature
aging and so on.
Artificial sweeteners such as...
Supplement
Supplement – what is it? Supplement is a term that means products made of one or more of the fundamental nutrients, for example vitamins, minerals, and proteins. It provides you with some specific (or a mix of) vitamins, minerals, herbs,...
Why Should I do a Body Detox & Internal Cleanse?
Detoxification therapy is the oldest known medical treatment on earth; it is a completely natural and necessary process to get you healthy and feeling your best. If you’ve never done an official detox program, you are long overdue for a...
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Folic Acid supplementation: long term safety is not an excuse for inaction
I share Lucock´s (1) concerns related to the fact that "the form of folate in supplements and in fortified foods is pteroylmonoglutamate (PGA), a form that does not occur in nature". The author is rightly critical of increasing tendency among clinicians to give supraphysiological doses of PGA.
In this regard, Ie would like to note that in Slovakia the single PGA is available only in 10 mg capsules. This dose is more than 20 times that needed to give maximal concentrations of the normal form of vitamin in plasma. Moreover, physicians are regularly prescribing up to 30mg/day of PGA according to the Prescription Drug Information.
The major concern, as Lucock point out, is that "we do not know the long-term biological effects of exposure to unmodified synthetic folate". In fact, there is evidence that neurological complications in patients with vitamin B12 deficiency (2) are not the only possible risk of folate supplementation. For example, animal and some clinical studies have suggested that folate supplementation in higher doses may increase cancer risk and accelerate tumor progression (3).
Because the long-term effects of PGA are not known, the best way of folate supplementation is through natural food. Those who are healthy and live healthy
life (including eating natural food rich in folate) do not need to take folate in its synthetic supplement form.
In certain situations, however, as is the case for some aged individuals and alcoholics, supplements containing recommended amounts of PGA may be warranted. (4,5) Nevertheless, the countries that adopted a policy of folate fortification of foods should provide monitoring of the benefits and possible harms of such fortification.
1. Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ 2004;328:211-4.
2. Reynolds EH. Benefits and risks of folic acid to the nervous system. J Neurol Neurosurg Psychiatry 2002;72:567-71.
3. Kim YI. Role of folate in colon cancer development and progression. J Nutr. 2003;133:3731S-3739S.
4. Bailey LB. Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations. J Nutr 2003;133:3748S-3753S.
5. Wharton B, Booth I. Fortification of flour with folic acid. BMJ 2001;323:1198-9.
About the author:
Dr. Michal R. Pijak is a consultant in rheumatology, allergy and clinical immunology at the University Hospital in Bratislava, Slovakia
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