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3 Things you want to know about Cholesterol
You wouldn't judge a book by its cover, would you? You would want to open the book and read part of it to get a better idea about what is going on, right? Well, judging a book by its cover is what happens when you look at LDL (bad)...
Adult Attention Deficit Disorder
Attention Deficit Disorder tends to focus predominately on children, leaving the ADD adult largely under served. Most of the information presented about Attention Deficit Disorder focuses on children, parenting and school issues. All but one...
Aloe Vera
Aloe Vera Aloe, native to Africa, is also known as "lily of the desert", the "plant of immortality", and the "medicine plant". The name was derived from the Arabic alloeh meaning "bitter" because of the bitter liquid found in the leaves. In...
Integrative Medicine And It's Future
The NBC National News, quoted the Washington Post in March of 2000, about the concerns that the FDA had over the mixing of supplements and conventional medications. There were concerns that millions of people are taking supplements (considered...
The Diet / Cancer Link
Attitudes to the link between diet and cancer are changing fast. The World Cancer Research Fund was founded specifically to fund and sponsor education and research into the diet-cancer link. There is mounting evidence that the high fat intake in...
 
Folic Acid supplementation: long term safety is not an excuse for inaction

I share Lucock´s (1) concerns related to the fact that "the form of folate in supplements and in fortified foods is pteroylmonoglutamate (PGA), a form that does not occur in nature". The author is rightly critical of increasing tendency among clinicians to give supraphysiological doses of PGA.

In this regard, Ie would like to note that in Slovakia the single PGA is available only in 10 mg capsules. This dose is more than 20 times that needed to give maximal concentrations of the normal form of vitamin in plasma. Moreover, physicians are regularly prescribing up to 30mg/day of PGA according to the Prescription Drug Information.

The major concern, as Lucock point out, is that "we do not know the long-term biological effects of exposure to unmodified synthetic folate". In fact, there is evidence that neurological complications in patients with vitamin B12 deficiency (2) are not the only possible risk of folate supplementation. For example, animal and some clinical studies have suggested that folate supplementation in higher doses may increase cancer risk and accelerate tumor progression (3).

Because the long-term effects of PGA are not known, the best way of folate supplementation is through natural food. Those who are healthy and live healthy


life (including eating natural food rich in folate) do not need to take folate in its synthetic supplement form.

In certain situations, however, as is the case for some aged individuals and alcoholics, supplements containing recommended amounts of PGA may be warranted. (4,5) Nevertheless, the countries that adopted a policy of folate fortification of foods should provide monitoring of the benefits and possible harms of such fortification.


1. Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ 2004;328:211-4.

2. Reynolds EH. Benefits and risks of folic acid to the nervous system. J Neurol Neurosurg Psychiatry 2002;72:567-71.

3. Kim YI. Role of folate in colon cancer development and progression. J Nutr. 2003;133:3731S-3739S.

4. Bailey LB. Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations. J Nutr 2003;133:3748S-3753S.

5. Wharton B, Booth I. Fortification of flour with folic acid. BMJ 2001;323:1198-9.

About the author:
Dr. Michal R. Pijak is a consultant in rheumatology, allergy and clinical immunology at the University Hospital in Bratislava, Slovakia



 

Office of Dietary Supplements - HOME
The mission of ODS is to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, stimulating and supporting ...
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A database of published, international, scientific literature on dietary supplements including vitamins, minerals, and botanicals.
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US FDA/CFSAN - Dietary Supplements: Overview
Overview of dietary supplements and the FDA's role in regulating this group of foods.
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Times Online - Supplements
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Drug Information and Supplement Information - MayoClinic.com
Research prescription and over-the-counter medications and supplements.
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Supplements : Nature
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Supplements Canada.com - Canada's Sport Supplement Superstore. Get ...
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Food and Nutrition Information Center: Dietary Supplements
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MMWR: Supplements Past Volumes
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