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A Healthy Life, the 4 Basics of a Healthy Life and the 3 Important Habits that Create Good Health
Good health is easy but being sick is hard. The truth is, maintaining good health is pretty simple although reclaiming it takes patience, consistent actions and smart choices. Your body heals at it's own pace. Your job is to help that process...
Healthier Skin Naturally in 7 Days or Less
Many people think that drastic measures are required in order to have flawless, youthful skin. Nothing could be further from the truth. It’s possible to have better looking skin starting with things you already have in your home; no cosmetic...
Moringa Leaf Powder - The World's Greatest Unknown Supplement
There is no doubt that the pure Moringa Tree leaf is the source of incredible health benefits. It's the ultimate, natural, organic, energy and endurance health supplement. There are plenty of studies that describe these benefits and the pure,...
No More Mr. Fuzz Face
Body image is a big issue for some and a small issue for others...but it is an issue of some kind for almost everybody. Some people feel they are too wide. Others feel they are too thin. Some are too bald. Others too graying. Some too tall....
Why Should I Take Nutritional Supplements?
Do you ever wonder why the experts keep saying that you need to take supplements? Why won't a healthy, balanced diet work? There are 3 main reasons that you need to take quality nutritional supplements each & every day. In this article, I want to...
 
Folic Acid supplementation: long term safety is not an excuse for inaction

I share Lucock´s (1) concerns related to the fact that "the form of folate in supplements and in fortified foods is pteroylmonoglutamate (PGA), a form that does not occur in nature". The author is rightly critical of increasing tendency among clinicians to give supraphysiological doses of PGA.

In this regard, Ie would like to note that in Slovakia the single PGA is available only in 10 mg capsules. This dose is more than 20 times that needed to give maximal concentrations of the normal form of vitamin in plasma. Moreover, physicians are regularly prescribing up to 30mg/day of PGA according to the Prescription Drug Information.

The major concern, as Lucock point out, is that "we do not know the long-term biological effects of exposure to unmodified synthetic folate". In fact, there is evidence that neurological complications in patients with vitamin B12 deficiency (2) are not the only possible risk of folate supplementation. For example, animal and some clinical studies have suggested that folate supplementation in higher doses may increase cancer risk and accelerate tumor progression (3).

Because the long-term effects of PGA are not known, the best way of folate supplementation is through natural food. Those who are healthy and live healthy


life (including eating natural food rich in folate) do not need to take folate in its synthetic supplement form.

In certain situations, however, as is the case for some aged individuals and alcoholics, supplements containing recommended amounts of PGA may be warranted. (4,5) Nevertheless, the countries that adopted a policy of folate fortification of foods should provide monitoring of the benefits and possible harms of such fortification.


1. Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ 2004;328:211-4.

2. Reynolds EH. Benefits and risks of folic acid to the nervous system. J Neurol Neurosurg Psychiatry 2002;72:567-71.

3. Kim YI. Role of folate in colon cancer development and progression. J Nutr. 2003;133:3731S-3739S.

4. Bailey LB. Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations. J Nutr 2003;133:3748S-3753S.

5. Wharton B, Booth I. Fortification of flour with folic acid. BMJ 2001;323:1198-9.

About the author:
Dr. Michal R. Pijak is a consultant in rheumatology, allergy and clinical immunology at the University Hospital in Bratislava, Slovakia



 

Office of Dietary Supplements - HOME
The mission of ODS is to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, stimulating and supporting ...
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International Bibliographic Information on Dietary Supplements ...
A database of published, international, scientific literature on dietary supplements including vitamins, minerals, and botanicals.
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US FDA/CFSAN - Dietary Supplements: Overview
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Research prescription and over-the-counter medications and supplements.
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Supplements : Nature
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MMWR: Supplements Past Volumes
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