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A Treatise Against Vivisection
A Dissertation to Charities Supporting Animal Experimentation
Introduction
I originally started this 08/08/01, but only got a few lines done. I planned to start it again later on, but when I went to go work on it, I realized that I...
Curing Cancer
Before Two Out Of Three Of Us Die From Cancer
Lifting the curse of the Big C. For years cancer has been seen as a death sentence and still brings out the fear of God in most of us today. We at Gen Cells Cures believe the tide is about to...
Personal care products can lead to Cancer
Our skin is a two way membrane. During perspiration toxins are eliminated from our body through it. Recently scientists have found that some chemicals when applied to the skin can penetrate the body and be absorbed by the body in significant...
Radiation: Too Much of a Good Thing
Radiation is wacky. We spend half our lives being terrified of it, and the other half rushing to the hospital to be voluntarily exposed to it. We're frightened at the thought of dirty nuclear bombs and concerned about too much exposure to medical...
What Do You Need To Know About Senior’s Health
As one progresses in age, he retreats in health or fitness. Though senior citizens are counseled to stay fit, it is barely the case like. Numerous natural transformations occur in the body as it moves towards fragility. For instance, the bones and...
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New Treatments that Offer Increased Hope for Osteoporosis Patients
(ARA) - For a time, hormone replacement therapy (the administration of estrogen either alone or in combination with other hormones) served as the preferred treatment for post-menopausal women hoping to reduce the progression of osteoporosis, a debilitating and inevitable bone-thinning disorder. Yet the latest findings from the prematurely halted Women’s Health Initiative (WHI) study on hormone replacement therapy alarmed many women. The study concluded that an estrogen and progestin combination used by thousands increased the risk of breast cancer, blood clots, heart attacks, and strokes when taken over a long period of time.
Osteoporosis is drastically accelerated during menopause and is the third leading cause of death of women over 70. By age 55, the average woman has already lost 30 percent of her bone mass. Eventually, bone loss can progress to the point where bones become so thin that they are susceptible to fracture from even the slightest trauma. According to the National Osteoporosis Foundation, one out of every two women over the age of 50 will have an osteoporosis-related fracture in her lifetime. Caucasian and Asian women are more likely to develop osteoporosis. However, African American and Hispanic women are at significant risk for developing the disease. Additionally, small-boned and thin women (under 127 pounds) are at greater risk for osteoporosis.
Many women are now searching for a safe alternative to hormone replacement therapy to alleviate the effects of osteoporosis. Current treatments on the market such as bisphosphonates and SERMs (estrogen-related therapies) have safety issues and focus primarily on slowing bone loss. Another existing treatment option is calcitonin, a naturally occurring hormone involved in calcium regulation and bone metabolism. In women who are more than five years beyond menopause calcitonin slows bone loss, increases spinal bone density and, according to recent studies, reduces the risk of spinal
fractures. In recent trials, calcitonin demonstrated a 62 percent reduction in the incidence of new vertebral fractures for a subgroup of women over 75, one of the most significant reductions demonstrated by any current osteoporosis therapy. In addition, calcitonin is the only osteoporosis therapy that can reduce the significant bone pain often associated with osteoporosis. Because calcitonin is a peptide, it cannot be taken orally because it would be digested before it could exert its therapeutic effect. Currently calcitonin is available as an injection or nasal spray. The U.S. Food and Drug Administration (FDA) is currently reviewing FORTICAL, a unique nasal calcitonin product developed by Unigene Laboratories, and Unigene is also developing an oral form of the product.
A new therapeutic option is parathyroid hormone (PTH), which can rebuild bone mass that has been lost due to osteoporosis. PTH has proven to increase the volume and strength of honeycomb-shaped bone mass located within the bone. This inner mesh contains blood vessels and bone marrow and begins to diminish after menopause. PTH helps reduce the incidence of fractures by restoring some of the lost bone architecture. Currently, PTH therapy is available only via daily injections. Unigene Laboratories and GlaxoSmithKline are jointly developing a PTH treatment that can be administered orally.
“Calcitonin has a proven, 25-year record of safe human use with virtually no side effects, and can be taken simultaneously with other medications,” said Dr. Warren Levy, president and CEO of Unigene. “After the WHI study, safety has become an even more important consideration because once a therapy is initiated, it should ideally be taken for life.”
For more information on osteoporosis and treatment options, please log on to www.unigene.com.
Courtesy of ARA Content
About the author:
Courtesy of ARA Content
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