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An Introduction of Chinese Traditional Medicine
The Chinese Traditional Medicine,known as the natural treatment medicine, considers a man's body as a part of the whole universe.So any changes of the universe system may cause the man's diseases.Excepting the astronomical terminal influence on the...
Cooling those hot flashes
YOU feel your face flushed in a warm unpleasant glow. Beads of sweat line your forehead and within moments you are desperately fanning yourself with the closest available file or magazine. Your clothes stick uncomfortably to you and you wish you had...
Is The Heat On? Maybe You’re Having A Hot Flash!
Is The Heat On? Maybe You’re Having A Hot Flash! Hot flashes are characterized by a sudden feeling of heat often accompanied with a reddening of the face and profuse sweating. For some, it is as mild as a brief warm flushing of the face and skin....
Is Vitamin E Lethal?
Recently the news carried the story that a researcher had discovered that taking vitamin E at a level of 400IU or more increases the risk of death. (Jan 2005, Annals of Internal Medicine http://www.annals.org/content/vol142/issue1/) I was...
Lunesta ...... miracle sleeping pill?
Copyright 2005 Wendy Owen
Lunesta! What's all the fuss about?
It even sounds festive doesn't it ? And it appears that with this sleep medication, there may well be cause for celebration!
It's been some months now since Lunesta first...
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Arthritis Drugs Celebrex-Vioxx Safety in Doubt
“Arthritis drugs Vioxx, Celebrex safety in doubt”
In doubt and may not be as safe as previously thought. Research earlier this
year has shown that these drugs increased the risk of heart attacks although a
relatively low risk, over those taking a pain reliever. The FDA is debating
whether to add information about the increased risk on both drugs’ labels.
One Wall Street analyst has warned that this problem could have an adverse
effect on Merck, the drug company responsible for these drugs be placed on the
market - along with Pharmacia, which makes Celebrex, generating $2.3 billion in
12 months to March 31 of this year, Merck having sold $1.7 billion Vioxx during
the same 12 months.
Studies done last year showed that patients taking Vioxx had four times the risk
of heart attacks over patients taking Naproxen - another pain reliever. Naproxen
is also sold under the brands names of Naprosyn and Aleve. The risk of heart
attacks increases over time, at about four heart attacks per 1,000 patients.
This study was sponsored by the Merck company, which also stated that their
research does not show this problem of increased heart attacks with Vioxx.
These two drugs are among the best-sellers of prescription drugs in the world.
They cause fewer ulcers that many other drugs given for pain. Richard R. Stover,
a pharmaceutical industry analyst at Arnhold & S. Bleichroeder Inc, reported on
April 27 that he did his own analysis on what he called “disturbing data” from
Merck’s study. He stated that he was warning his clients, many of whom were
institutional investors holding stock in Merck, that they should watch the issue
carefully because it could effect the company’s stock price.
Dr. M. Michael Wolfe, chief of the gastroenterology section at the Boston
University School of Medicine and a member of the FDA advisory committee stated
that there should be a warning, after a review of the issue earlier this year,
stating that
“The marketing of these drugs is unbelievable, I’m sure there are many people
out there who are taking these drugs that should not be.”
There is a current debate going on between some doctors and Merck’s scientists
as to whether the higher risk of heart attacks is a result of Vioxx causing
damage in some patients or to an absence of the benefits that Naproxen may have
in protecting the heart, that Naproxen stops or slows the production of
thromboxane, which is thought to cause platelet in the blood to form clots,
similar to the aspirin effect.
Vioxx and Celebrex have been shown to have the same benefit in protecting the
heart.
Several doctors say they are worried about the possibility of heart attacks
because many of the arthritis patients
taking the drugs are elderly and have a
higher risk of cardiovascular problems to begin with.
The current debate centers on whether the higher heart attack rate found in
patients taking Vioxx is a result of the drug’s actually causing damage in some
patients or to an absence of the heart-protecting benefits that Naproxen may
have.
“Naproxen had a similar anti-platelet effect to aspirin,” said Dr. Eve E.
Slater, senior vice president of external policy for Merck’s research labs,
“and those people had fewer heart attacks.”
Neither Vioxx nor Celebrex has been shown to have the same heart-protecting
benefit.
Slater also said that Stover’s report was flawed and biased in favor of
Pharmacia. But regulators and some doctors say they still worry that there may
be more of a problem with Vioxx.
And even if Vioxx and Celebrex do not damage the heart, the fact that they do
not have the heart-protecting benefits of aspirin reduces the ability of the
companies to market them as being significantly safer than other pain relievers.
Merck recommended last year that doctors involved in clinical trials of Vioxx
consider prescribing low doses of aspirin to patients taking Vioxx if they are
at high risk of heart attacks - although low doses of aspirin could increase the
risk of ulcers. Ulcers are the main side effect that Vioxx and Celebrex were
developed to avoid.
There have been no studies done to determine whether patients have fewer ulcers
if they take low doses of aspirin with either Vioxx or Celebrex. In February
Dr Maria Lourdes Villalba, at an FDA advisory meeting, stated that Merck had
proved Vioxx [Rofecoxib] caused fewer serious ulcers than Naproxen. However,
she also state that the potential safety advantage was offset by a higher risk
of heart problems,in her opinion. She reported that “Overall, there was no
safety superiority of Rofecoxib over Naproxen, mainly due to an excess of serious
cardiovascular events”.
Dr Villalba also stated that there had been no studies to prove Merck’s claim that
Naproxen worked like aspirin in decreasing heart attacks. The FDA expressed some
concern over the higher rate of heart attacks with Vioxx, stating that this could
be caused by the drug’s ability to produce blood clots.
“There is still a tremendous benefit with these drugs” reported Dr Eve Slater of
Merck.
About the Author
Margot B, Writer, Web Developer
Margot B has written a book and hundreds of articles, specializing in health and the environment.
mailto:margotb@wonderport.com
Web Sites by Margot B:
http://margot.bravepages.com
http://margotsnews.gossimer.net
http://websitebuilder4free.Biz-Page.com
http://www.freewebz.com/nuchatlaht
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